期刊
CELLULAR & MOLECULAR BIOLOGY LETTERS
卷 19, 期 4, 页码 561-575出版社
DE GRUYTER OPEN LTD
DOI: 10.2478/s11658-014-0212-6
关键词
lncRNAs; Mechanisms; Dynamic expression; Chromatin state; Transcription factor; Specific DNA sequence; microRNA; Post-transcriptional regulation
资金
- Chinese Academy of Sciences
- Guangdong Province Guangdong Science and Technology Plan Project [2009B091300129]
- Science and Technology Development project of Guangzhou [2010UI-E00531-7]
Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.
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