期刊
BRAIN & DEVELOPMENT
卷 25, 期 1, 页码 45-50出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0387-7604(02)00154-7
关键词
magnetic resonance spectroscopy; giant axonal neuropathy; demyelination; leukoencephalopathy
Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter. (C) 2002 Elsevier Science B.V. All rights reserved.
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