期刊
IUBMB LIFE
卷 55, 期 1, 页码 13-22出版社
WILEY
DOI: 10.1080/1521654031000070645
关键词
herpes virus; lytic replication; latency; recombination; initiation; gene expression
资金
- NIGMS NIH HHS [GM62643] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062643] Funding Source: NIH RePORTER
Herpesviruses are large double stranded DNA animal viruses with the distinguishing ability to establish latent, life-long infections. To date, eight human herpesviruses that exhibit distinct biological and corresponding pathological/clinical properties have been identified. During their life cycles, herpesviruses execute an intricate chain of events geared towards optimizing their replication. This sets an interesting paradigm to study fundamental biological processes. This review summarizes recent developments in herpesvirus research with emphasis on genome transactions, particularly with respect to the prototypic herpes simplex virus type-1.
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