期刊
CELLS TISSUES ORGANS
卷 195, 期 1-2, 页码 73-81出版社
KARGER
DOI: 10.1159/000331413
关键词
Vascular development; Stem cell; Progenitor cell niche
资金
- NIH [HL-93594, HL-88374, HL-87513]
- American Heart Association [09PRE2060165]
- University of North Carolina at Chapel Hill
- Seattle Children's Research Institute
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL093594, K99HL087513, R01HL088374, R00HL087513] Funding Source: NIH RePORTER
Recent observations suggest that the adventitial layer of blood vessels exhibits properties resembling a stem/progenitor cell niche. Progenitor cells have been isolated from the adventitia of both murine and human blood vessels with the potential to form endothelial cells, mural cells, osteogenic cells, and adipocytes. These progenitors appear to cluster at or near the border zone between the outer media and inner adventitia. In the mouse, this border zone region corresponds to a localized site of sonic hedgehog signaling in the artery wall. This brief review will discuss the emerging evidence that the tunica adventitia may provide a niche-like signaling environment for resident progenitor cells and will address the role of the adventitia in growth, remodeling, and repair of the artery wall. Copyright (C) 2011 S. Karger AG, Basel
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