期刊
JOURNAL OF STRUCTURAL BIOLOGY
卷 141, 期 1, 页码 53-62出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1047-8477(02)00576-2
关键词
second harmonic generation; collagen; 3D reconstruction; cirrhosis
Collagen is the most important structural protein of the animal body. Its unique triple-helix structure and extremely high level of crystallinity make it exceptionally efficient in generating the second harmonic of incident light, and we show here how this leads to a novel mode of microscopy of immediate practical significance in medicine and biology. In particular, it provides sensitive and high-resolution information on collagen distribution, discriminates between type I and type III collagen, and allows both a greater understanding of and a sensitive test for cirrhosis of the liver. Future research applications could include wound healing and hereditary collagen diseases such as osteogenesis imperfecta. (C) 2002 Elsevier Science (USA). All rights reserved.
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