期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 29, 期 2, 页码 241-246出版社
MARCEL DEKKER INC
DOI: 10.1081/DDC-120016732
关键词
pentoxifylline; xanthan gum; controlled release; matrix tablets
Pentoxifylline-controlled release tablets were prepared using xanthan gum. The effects of polymer concentration, rotation speed, ionic strength, and pH of the dissolution medium on the release of the water-soluble pentoxifylline were studied. The release rate decreased with increasing polymer concentration in the tablet, which was reflected in the increase in the mean dissolution time. A higher rotation speed and increased ionic strength of the dissolution medium resulted in a higher rate of drug release of xanthan-based tablets. A higher release rate of pentoxifylline was also observed using acidic dissolution medium.
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