期刊
TRENDS IN GENETICS
卷 19, 期 1, 页码 2-5出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(02)00008-2
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资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [K22HG002451] Funding Source: NIH RePORTER
- NHGRI NIH HHS [1 K22 HG 02451-01] Funding Source: Medline
The number and role of whole-genome duplications in vertebrate evolution has intrigued evolutionary biologists since Ohno first proposed genome duplication as the force driving the 'big leap' in vertebrate morphological innovation. Attempts to resolve these issues have been thwarted by small and noisy datasets, and by lack of computational accuracy and statistical rigor. Recently, Ken Wolfe and colleagues presented a genome-scale, statistically rigorous analysis of evidence based on the spatial organization of duplicated genes, as well as estimates of duplication times. Their results provide the strongest evidence to date of large-scale duplication throughout the vertebrate genome, consistent with at least one whole-genome duplication.
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