期刊
CHIRALITY
卷 15, 期 -, 页码 S104-S107出版社
WILEY-LISS
DOI: 10.1002/chir.10261
关键词
alpha-aminophosphonates; diastereomers; zinc protease; inhibitors; LAP
The stereoselective synthesis of 1-amino-2-alkylalkanephosphonic acids, namely, compounds bearing two chiral centers, was achieved by the condensation of hypophosphorous acid salts of (R) (+) or (S) (-)-N-alpha-methylbenzylamine with the appropriate aldehydes in isopropanol. Simultaneous deprotection and oxidation by the action of bromine water provided equimolar mixtures of the RS:RR and SR:SS diastereomers of desired acids. They appeared to act as moderate inhibitors of kidney leucine aminopeptidase with potency dependent on the absolute configuration of both centers of chirality. (C) 2003 Wiley-Liss, Inc.
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