期刊
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
卷 41, 期 1, 页码 85-87出版社
MARCEL DEKKER INC
DOI: 10.1081/CLT-120018277
关键词
baclofen; withdrawal; intrathecal baclofen; GABA B agonist
类别
Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.
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