期刊
CELL TRANSPLANTATION
卷 23, 期 4-5, 页码 459-469出版社
SAGE PUBLICATIONS INC
DOI: 10.3727/096368914X678418
关键词
Lethal-7 (let-7); Stemness; Cancer therapy
资金
- National Science Council [NSC 98-2314-B-039-008-MY2, NSC 102-2314-B-039-022, NSC 102-2314-B-039-021-MY3]
- China Medical University and Hospital [CMU99-N2-01-(12), DMR-101-116, DMR-102-053]
The first microRNA, let-7, and its family were discovered in Caenorhabditis elegans and are functionally conserved from worms to humans in the regulation of embryonic development and sternness. The let-7 family has been shown to have an essential role in stem cell differentiation and tumor-suppressive activity. Deregulating expression of let-7 is commonly reported in many human cancers. Emerging evidence has accumulated and suggests that reestablishment of let-7 in tumor cells is a valuable therapeutic strategy. However, findings reach beyond tumor therapeutics and may impinge on sternness and differentiation of stem cells. In this review, we discuss the role of let-7 in development and differentiation of normal adult stem/progenitor cells and offer a viewpoint of the association between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the application of let-7 are highlighted.
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