期刊
GENOME BIOLOGY
卷 4, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2003-4-10-r67
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资金
- NCI NIH HHS [R01 CA058554, P30CA16058, R01CA58554, P30 CA016058] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA058554, P30CA016058] Funding Source: NIH RePORTER
Logit-t employs a logit-transformation for normalization followed by statistical testing at the probe-level. Using four publicly-available datasets, together providing 2,710 known positive incidences of differential expression and 2,913,813 known negative incidences, performance of statistical tests were: Logit-t provided 75% positive-predictive value, compared with 5% for Affymetrix Microarray Suite 5, 6% for dChip perfect match (PM)-only, and 9% for Robust Multi-array Analysis at the p < 0.01 threshold. Logit-t provided 70% sensitivity, Microarray Suite 5 provided 46%, dChip provided 53% and Robust Multi-array Analysis provided 63%.
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