期刊
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 33, 期 1, 页码 63-71出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0965-1748(02)00168-6
关键词
Culex quinquefasciatus; salivary glands; mosquito bite allergy
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI029746, R37AI029746] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI29746] Funding Source: Medline
The sera of persons with strong allergic responses to the bites of the mosquito, Culex quinquefasciatus, contained IgE antibodies reactive with two major salivary-gland proteins with molecular weights of 35 and 28 kDa. These antigens were purified, their amino termini sequenced, and the sequences were used to search for similar sequences in public databases. Two cDNAs, CuQu-D7CIu1 and CuQu-D7Clul2, which encode D7-related proteins, were identified as containing predicted amino acid sequences identical to the 35 and 28 kDa antigens, respectively. These proteins are expressed specifically in adult female salivary glands and, their predicted tertiary structures are consistent with a role as carriers of hydrophobic molecules in mosquito saliva. (C) 2002 Elsevier Science Ltd. All rights reserved.
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