期刊
CELL TRANSPLANTATION
卷 22, 期 3, 页码 529-533出版社
SAGE PUBLICATIONS INC
DOI: 10.3727/096368911X637461
关键词
Congestive heart failure (HF); Left ventricular (LV) mechanics; Tissue engineering; Alginate hydrogel
资金
- LoneStar Heart, Inc.
Heart failure continues to be a major health care concern with relatively few options for severely advanced heart failure patients. The hallmark of heart failure is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen consumption. Applying Laplace's law to the failing dilated ventricle, left ventricular augmentation utilizes a tissue engineering strategy to increase wall thickness and reduce chamber diameter, resulting in a decrease in wall stress and improved left ventricular function. A review of the rationale for an in situ tissue engineering approach for this treatment of heart failure and early clinical results of the Algisyl-LVR (TM) program are presented.
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