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Sarah L. Anderson et al.
ANNALS OF PHARMACOTHERAPY (2010)
Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients
U. Pugazhenthi et al.
DIABETOLOGIA (2010)
EXENATIDE-INDUCED ACUTE PANCREATITIS
Walaa A. Ayoub et al.
ENDOCRINE PRACTICE (2010)
Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation
Y. Kawasaki et al.
HORMONE AND METABOLIC RESEARCH (2010)
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression
Le Thi Kim Chung et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Long-Term Metabolic and Hormonal Effects of Exenatide on Islet Transplant Recipients With Allograft Dysfunction
Raquel N. Faradji et al.
CELL TRANSPLANTATION (2009)
Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis
Luiz F. Rezende et al.
CYTOKINE (2009)
Anti-apoptotic Action of Exendin-4 in INS-1 Beta Cells: Comparative Protein Pattern Analysis of Isolated Mitochondria
D. Tews et al.
HORMONE AND METABOLIC RESEARCH (2009)
Exendin-4 inhibits interleukin-1β-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F β-cells
Jung-Hoon Kang et al.
JOURNAL OF ENDOCRINOLOGY (2009)
Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
Sehee Kim et al.
JOURNAL OF ENDOCRINOLOGY (2009)
Impact of Pancreatic Cold Preservation on Rat Islet Recovery and Function
Antonello Pileggi et al.
TRANSPLANTATION (2009)
Islet transplantation for brittle type 1 diabetes: The UIC protocol
A. Gangemi et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2008)
Riboflavin inhibits IL-6 expression and p38 activation in islet cells
Lorenzo Cobianchi et al.
CELL TRANSPLANTATION (2008)
Exendin-4 protects β-cells from interleukin-1β-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
Mourad Ferdaoussi et al.
DIABETES (2008)
STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3β
Akira Moh et al.
DIABETES (2008)
Cytokines and β-cell biology:: from concept to clinical translation
Marc Y. Donath et al.
ENDOCRINE REVIEWS (2008)
Enhanced protection against cytokine- and fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues
D. Tews et al.
HORMONE AND METABOLIC RESEARCH (2008)
Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas
Ditte Tornehave et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2008)
Anti-proliferative effect of pro-inflammatory cytokines in cultured β cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition:: protective role of glucagon-like peptide-1
M. Blandino-Rosano et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2008)
Characterization of pancreatic ductal cells in human islet preparations
Hirohito Ichii et al.
LABORATORY INVESTIGATION (2008)
Exenatide and Rare Adverse Events
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Interleukin-6 regulates pancreatic α-cell mass expansion
Helga Ellingsgaard et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The use of exenatide in islet transplant recipients with chronic allograft dysfunction: Safety, efficacy, and metabolic effects
Tatiana Froud et al.
TRANSPLANTATION (2008)
Long-Term Insulin Independence and Improvement in Insulin Secretion After Supplemental Islet Infusion Under Exenatide and Etanercept
Raquel N. Faradji et al.
TRANSPLANTATION (2008)
Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation
A. Fornoni et al.
DIABETOLOGIA (2008)
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model
Dora M. Berman et al.
TRANSPLANTATION (2007)
The L-isoform but not D-isoforms of a JNK inhibitory peptide protects pancreatic β-cells
Alessia Fornoni et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Effect of exenatide on β cell function after islet transplantation in type 1 diabetes
Khalid Al Ghofaili et al.
TRANSPLANTATION (2007)
Automated, high-throughput assays for evaluation of human pancreatic islet function
Over Cabrera et al.
CELL TRANSPLANTATION (2007)
Shipment of human islets for transplantation
H. Ichii et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2007)
Expression of high levels of human proteinase inhibitor 9 blocks both perforin/granzyme and Fas/Fas ligand-mediated cytotoxicity
Thomas D. Cunningham et al.
CELLULAR IMMUNOLOGY (2007)
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
Daniel J. Drucker et al.
LANCET (2006)
GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts
Gang Xu et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2006)
Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
L. Blonde et al.
DIABETES OBESITY & METABOLISM (2006)
Investigation of exenatide elimination and its in vivo and in vitro degradation
Kathrin Copley et al.
CURRENT DRUG METABOLISM (2006)
Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells
XG Jiang et al.
ENDOCRINOLOGY (2006)
Exendin-4 uses Irs2 signaling to mediate pancreatic β cell growth and function
S Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Exenatide (Exendin-4) improves insulin sensitivity and β-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
BR Gedulin et al.
ENDOCRINOLOGY (2005)
A randomized, open-label, crossover study examining the effect of injection site on bioavallability of exenatide (synthetic exendin-4)
F Calara et al.
CLINICAL THERAPEUTICS (2005)
Prolonged allogeneic islet graft survival by protoporphyrins
A Pileggi et al.
CELL TRANSPLANTATION (2005)
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-Jun NH2-terminal kinase mediates survival of isolated human islets
R Aikin et al.
ENDOCRINOLOGY (2004)
Caspase-3 inhibitor prevents apoptosis of human islets immediately after isolation and improves islet graft function
M Nakano et al.
PANCREAS (2004)
Circulation and degradation of GIP and GLP-1
CF Deacon
HORMONE AND METABOLIC RESEARCH (2004)
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure
S Abdelli et al.
DIABETES (2004)
IP-10 and type 1 diabetes: A question of time and location
U Christen et al.
AUTOIMMUNITY (2004)
Response of human islets to isolation stress and the effect of antioxidant treatment
R Bottino et al.
DIABETES (2004)
Inflammatory mechanisms in diabetes:: lessons from the β-cell
HE Hohmeier et al.
INTERNATIONAL JOURNAL OF OBESITY (2003)
Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
L Farilla et al.
ENDOCRINOLOGY (2003)
Enhancing incretin action for the treatment of type 2 diabetes
DJ Drucker
DIABETES CARE (2003)
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
HX Hui et al.
ENDOCRINOLOGY (2003)
Modulators of inflammation use nuclear factor-KB and activator protein-1 sites to induce the caspase-1 and granzyme B inhibitor, proteinase inhibitor 9
P Kannan-Thulasiraman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
BA Bladergroen et al.
BLOOD (2002)
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
KJ Livak et al.
METHODS (2001)
The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
BA Bladergroen et al.
JOURNAL OF IMMUNOLOGY (2001)
Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans - Insulin as an autocrine survival signal
S Paraskevas et al.
ANNALS OF SURGERY (2001)
Cell-permeable peptide inhibitors of JNK novel blockers of beta-cell death
C Bonny et al.
DIABETES (2001)
The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1β-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
JL Young et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)