期刊
CELL TRANSPLANTATION
卷 21, 期 11, 页码 2407-2424出版社
SAGE PUBLICATIONS INC
DOI: 10.3727/096368912X637055
关键词
Adipose tissue-derived stem cells (ASCs); Angiotensin II; Fibrosis; Losartan; Muscle laceration; Transforming growth factor-beta (TGF-beta)
资金
- Basic Science Research Program through the National Research Foundation (NRF) of Korea
- Ministry of Education, Science, and Technology [2010-0022587]
- National Research Foundation of Korea [2010-0022587] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Recently, adipose tissue-derived stem cells (ASCs) were emerged as an alternative, abundant, and easily accessible source of stem cell therapy. Previous studies revealed losartan (an angiotensin II type I receptor blocker) treatment promoted the healing of skeletal muscle by attenuation of the TGF-beta signaling pathway, which inhibits muscle differentiation. Therefore, we hypothesized that a combined therapy using ASCs and losartan might dramatically improve the muscle remodeling after muscle injury. To determine the combined effect of losartan with ASC transplantation, we created a muscle laceration mouse model. EGFP-labeled ASCs were locally transplanted to the injured gastrocnemius muscle after muscle laceration. The dramatic muscle regeneration and the remarkably inhibited muscular fibrosis were observed by combined treatment. Transplanted ASCs fused with the injured or differentiating myofibers. Myotube formation was also enhanced by ASC(+). satellite coculture and losartan treatment. Thus, the present study indicated that ASC transplantation effect for skeletal muscle injury can be dramatically improved by losartan treatment inducing better niche.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据