期刊
CELL TRANSPLANTATION
卷 18, 期 9, 页码 1013-1028出版社
SAGE PUBLICATIONS INC
DOI: 10.3727/096368909X471206
关键词
Mesenchymal stem cells; Stem cell therapy; Immunoregulation; Myocardial infarction; Hepatic failure; Ocular disease
Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the past decade has revealed differentiation potentials of mesenchymal stem cells beyond lineages of the mesoderm, suggesting broader applications than originally perceived. In this article, we review the recent developments in mesenchymal stem cell research with respect to their emerging properties and applications in nonmusculoskeletal diseases.
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