期刊
MOLECULAR PSYCHIATRY
卷 8, 期 6, 页码 611-618出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001354
关键词
genetics; CREB1; depression; sex-specific; women
资金
- NCRR NIH HHS [1-P41-RR03655] Funding Source: Medline
- NIMH NIH HHS [MH00540, MH60866, MH48969] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR003655] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060866, R01MH048969] Funding Source: NIH RePORTER
Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women ( but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451 kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions.
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