期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 31, 期 6, 页码 509-516出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323000303100607
关键词
hyaluronic acid; gel film; rat caecal model; abdominal surgery; post-operative adhesion; adhesion prevention; wound healing
This study evaluated the efficacy of a novel hyaluronic acid (HA) gel for preventing adhesions in a rat caecal model. The gel was manufactured from an acidic HA solution using a freezing procedure. HA gel films with four different half-lives (50 - 200 h) in physiological buffered saline at 37degreesC were prepared, by regulating the freezing time, and tested. The HA gel film was applied as a barrier on the injured caecal surface after standardized treatment with a rotary abrasion apparatus. A control group of 20 animals were abraded in the same way but not treated. Seven days after the initial operation, the incidence and severity of any adhesions were recorded. Application of the HA gel film significantly reduced the incidence and severity of adhesion formation in all treatment groups compared with the control group. This novel HA gel film is effective for reducing post-operative adhesions in this rat model and the resorption rate is optimum for adhesion prevention on the caecal surface.
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