期刊
AMINO ACIDS
卷 25, 期 3-4, 页码 313-321出版社
SPRINGER WIEN
DOI: 10.1007/s00726-003-0019-7
关键词
nitric oxide; redox cell signaling; reactive nitrogen species; protein modification; redox tone
资金
- NHLBI NIH HHS [HL58031] Funding Source: Medline
- NIAAA NIH HHS [AA13395] Funding Source: Medline
- NIEHS NIH HHS [ES10167] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL058031] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES010167] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA013395] Funding Source: NIH RePORTER
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have an impact on many cellular processes, often serving as signal transducers in both physiological and pathological situations. These small molecules can act as ligands for receptors as is the case for nitric oxide and guanylate cyclase. However, they can also modify proteins, changing their function and establishing a baseline for other signals in a process that we have termed redox tone.'' In this review, we discuss the different mechanisms of redox cell signaling, and give specific examples of RNS participation in cell signaling via classical and redox tone pathways.
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