期刊
CELL STEM CELL
卷 15, 期 6, 页码 762-774出版社
CELL PRESS
DOI: 10.1016/j.stem.2014.10.001
关键词
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资金
- BIDMC
- Sidney Kimmel Cancer Research Foundation
- Susan G. Komen For The Cure
- AIRC [IG14201]
- Compagnia di San Paolo [2008.1054]
- Progetto Ricerca Ateneo Torino
- BIDMC Prostate and Breast Cancer Research Program
Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast tumor stroma formation and to promote metastasis. Despite expanding knowledge of their contributions to breast malignancy, the underlying molecular responses of breast cancer cells (BCCs) to MSC influences remain incompletely understood. Here, we show that MSCs cause aberrant expression of microRNAs, which, led by microRNA-199a, provide BCCs with enhanced cancer stem cell (CSC) properties. We demonstrate that such MSC-deregulated microRNAs constitute a network that converges on and represses the expression of FOXP2, a forkhead transcription factor tightly associated with speech and language development. FOXP2 knockdown in BCCs was sufficient in promoting CSC propagation, tumor initiation, and metastasis. Importantly, elevated microRNA-199a and depressed FOXP2 expression levels are prominent features of malignant clinical breast cancer and are associated significantly with poor survival. Our results identify molecular determinants of cancer progression of potential utility in the prognosis and therapy of breast cancer.
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