期刊
CONNECTIVE TISSUE RESEARCH
卷 44, 期 -, 页码 298-299出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03008200390181807
关键词
eruption; MT1-MMP; periodontal ligament; root growth
资金
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000676] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [Z01DE000676] Funding Source: NIH RePORTER
To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.
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