期刊
CELL STEM CELL
卷 13, 期 5, 页码 535-548出版社
CELL PRESS
DOI: 10.1016/j.stem.2013.08.012
关键词
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资金
- Medical Research Council UK [H4RPLK0]
- Knut och Alice Wallenberg Foundation (WIRM)
- StratRegen, KI
- EU
- ALF
- Swedish Research Council Linnaeus
- MRC Molecular Haematology Unit
- Leukaemia and Lymphoma Research
- Swedish Cancer foundation
- Swedish Society of Medicine
- Crafoord Foundation
- Georg Danielsson's foundation
- MRC [MC_UU_12009/5, G84/6443, G0801073, MC_UU_12009/2, G0501838, G0900867, MC_U137970202] Funding Source: UKRI
- Medical Research Council [MC_U137970202, G0900867, G1000801h, G84/6443, MC_UU_12009/5, MC_UU_12009/2, G0801073, G0501838] Funding Source: researchfish
In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important line-age-commitment step in mammalian hematopoiesis.
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