期刊
CELL STEM CELL
卷 13, 期 4, 页码 433-445出版社
CELL PRESS
DOI: 10.1016/j.stem.2013.07.004
关键词
-
资金
- UCL Institute of Child Health
- Great Ormond Street Hospital Flow Cytometry Core Facility
- Montpellier RIO Imaging Cytometry Facility
- UCL Genomics
- ICH Embryonic Stem Cell/Chimera Production Facility
- UCL Biological Services Unit
- UCL Cancer Institute
- WIBR Scientific Support Services
- Wellcome Trust [086545, 084361]
- Great Ormond Street Children's Hospital Charity
- Great Ormond Street Hospital Childrens Charity [V1255, W1055] Funding Source: researchfish
- Medical Research Council [MC_U117570590] Funding Source: researchfish
- MRC [MC_U117570590] Funding Source: UKRI
Sox2(+) adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their physiological role in vivo and possible contribution to oncogenesis remain largely unknown. Using genetic lineage tracing, we show here that the Sox2(+) cell compartment of both the embryonic and adult pituitary contains stem/progenitor cells that are able to differentiate into all hormone-producing lineages and contribute to organ homeostasis during postnatal life. In addition, we show that targeted expression of oncogenic beta-catenin in Sox2(+) cells gives rise to pituitary tumors, but, unexpectedly, the tumor mass is not derived from the Sox2(+) mutation-sustaining cells, suggesting a paracrine role of Sox2(+) cells in pituitary oncogenesis. Our data therefore provide in vivo evidence of a role for Sox2(+) stem/progenitor cells in long-term physiological maintenance of the adult pituitary, and highlight an unexpected non-cell-autonomous role for these cells in the induction of pituitary tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据