期刊
CELL STEM CELL
卷 13, 期 2, 页码 149-159出版社
CELL PRESS
DOI: 10.1016/j.stem.2013.07.001
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIDDK NIH HHS [U01 DK089565, U01DK089565] Funding Source: Medline
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of these variations for iPSC applications, and propose approaches to cope with these variations.
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