The Young and the Restless: Regulation of Adult Neurogenesis by Wnt Signaling

Wnt signaling plays a critical role in developmental and adult neurogenesis. In this issue of Cell Stem Cell, Jang et al. (2013) and Seib et al. (2013) show how age and neuronal activity regulate adult hippocampal neurogenesis by inhibiting or activating, respectively, distinct components of the Wnt signaling machinery.