期刊
CELL STEM CELL
卷 9, 期 6, 页码 527-540出版社
CELL PRESS
DOI: 10.1016/j.stem.2011.10.002
关键词
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资金
- Victorian State Government
- Australian Stem Cell Centre [PO82, S4M1]
- National Health and Medical Research Counsel Australia [354400, 573705, 573707, 535903]
- Australia-India Strategic Research Fund [BF020084]
- Johnson and Johnson
- Atlantic Philanthropies [19131]
- Cancer Institute New South Wales [09/CDF/2-40, 10/CRF/1-01]
- Australian Cancer Research Foundation
- Royal Australian College of Surgeons
- Avner Nahmani Pancreatic Cancer Foundation
- R. T. Hall Trust
- National Heart Foundation of Australia (NHF)
- NHF [CR 08S3958]
Colony-forming units fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perk vascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
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