期刊
CELL STEM CELL
卷 9, 期 6, 页码 517-525出版社
CELL PRESS
DOI: 10.1016/j.stem.2011.11.015
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资金
- NIMH NIH HHS [R01 MH092931] Funding Source: Medline
- NINDS NIH HHS [RC4 NS073015] Funding Source: Medline
Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.
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