4.7 Editorial Material

Getting to the Core of Repeat Expansions by Cell Reprogramming

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CELL STEM CELL
卷 7, 期 5, 页码 545-546

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CELL PRESS
DOI: 10.1016/j.stem.2010.10.005

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  1. NIGMS NIH HHS [R01 GM060987] Funding Source: Medline

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In this issue of Cell Stem Cell, Ku et al. (2010) demonstrate that iPSCS derived from Friedreich's ataxia patients exhibit expansion of the causative (GAA)(n) repeat, consistent with the repeat instability observed during intergenerational transmissions in humans. Furthermore, the epigenetic signature of the disease remains intact in Friedreich's ataxia iPSCs.

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