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SKP-ing TAp63: Stem Cell Depletion, Senescence, and Premature Aging

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CELL STEM CELL
卷 5, 期 1, 页码 1-2

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CELL PRESS
DOI: 10.1016/j.stem.2009.06.015

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The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial development. In this issue of Cell Stem Cell, by generating isoform-specific knockout mice, Su et al. (2009) reveal pivotal roles for TAp63 in the maintenance of dermal and epidermal precursors, genomic stability, and organismal longevity.

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