期刊
CELL STEM CELL
卷 3, 期 3, 页码 301-313出版社
CELL PRESS
DOI: 10.1016/j.stem.2008.07.003
关键词
-
资金
- Department of Defense
- Commonwealth of Pennsylvania
- Children's Hospital of Pittsburgh
- University of Pittsburgh Cancer Institute
- National Institutes of Health [RO1 #AR49684-01, R21 #HL083057-01A2]
- Banca San Paolo of Turin, Italy
Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-R beta expression and absence of hematopoietic, endothelial, and myogenic cell markers. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity; exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials; expressed MSC markers; and migrated in a culture model of chemotaxis. Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. Thus, blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据