期刊
CELL RESEARCH
卷 24, 期 1, 页码 69-79出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cr.2013.161
关键词
autophagy; lysosome; neurodegeneration; Parkinson's disease; mitophagy; Crohn's disease; SENDA
类别
资金
- Funding Program for Next Generation World-Leading Researchers
- JSPS KAKENHI [25111005]
- Scholarship Council in China
- Ministry of Education, Culture, Sports, Science, and Technology in Japan
- Grants-in-Aid for Scientific Research [25111001] Funding Source: KAKEN
Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to the lysosome for degradation. Since the discovery of autophagy-related (Atg) genes in the 1990s, there has been a proliferation of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models. However, direct evidence of the connections between ATG gene dysfunction and human diseases has emerged only recently. There are an increasing number of reports showing that mutations in the ATG genes were identified in various human diseases such as neurodegenerative diseases, infectious diseases, and cancers. Here, we review the major advances in identification of mutations or polymorphisms of the ATG genes in human diseases. Current autophagy-modulating compounds in clinical trials are also summarized.
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