期刊
TRENDS IN MOLECULAR MEDICINE
卷 9, 期 1, 页码 36-41出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4914(02)00009-6
关键词
-
资金
- NATIONAL CANCER INSTITUTE [Z01BC010025, ZIABC010025] Funding Source: NIH RePORTER
There are still many unanswered questions regarding the processes by which extracellular signals are transduced from plasma-membrane receptors to the transcription machinery in the nucleus and the translation machinery in the cytoplasm. Some of these gene expression events become misregulated as a result of environmental or endogenous exposure to agents that cause multistage carcinogenesis. We are now beginning to identify and validate the crucial molecular events that drive the rate-limiting steps of carcinogenesis and to target these events for cancer prevention. Transcription factors AP-1 and nuclear factor kappaB can be specifically targeted to prevent cancer induction in mouse models. A protein known as program med-cell-death-4 is a new potential molecular target that has a surprising mode of action.
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