期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 80, 期 3, 页码 285-290出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1074-7427(03)00062-5
关键词
auditory cortex; thalamocortical; nicotinic acetylcholine receptor; nicotine; development; rat
资金
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R55DC002967, R01DC002967, R29DC002967] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA012929] Funding Source: NIH RePORTER
- NIDA NIH HHS [DA12929] Funding Source: Medline
- NIDCD NIH HHS [DC02967] Funding Source: Medline
Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and fuctions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activation in auditory cortex and describe how these actions could affect systems-level auditory function. In particular, we describe a novel function of nicotinic actylcholinc receptors to regulate glutamate synapses containing N-methyl-D-aspartate receptors during early postnatal development. The transient regulation of developing glutamate synapses also defines a window of vulnerability during which exposure to exogenous nicotine disrupts synapse development. Thus. it appears that nicotinic regulation of glutamate synapses is a critical feature of auditory cortex development. (C) 2003 Elsevier Science (USA). All rights reserved.
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