4.8 Review

New insights into p53 activation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Blinded by the Light: The Growing Complexity of p53

Karen H. Vousden et al.

Review Biochemistry & Molecular Biology

Modes of p53 Regulation

Jan-Philipp Kruse et al.

Article Biochemistry & Molecular Biology

MSL2 Promotes Mdm2-independent Cytoplasmic Localization of p53

Jan-Philipp Kruse et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Cytoplasmic functions of the tumour suppressor p53

Douglas R. Green et al.

NATURE (2009)

Review Oncology

How does SIRT1 affect metabolism, senescence and cancer?

Christopher L. Brooks et al.

NATURE REVIEWS CANCER (2009)

Editorial Material Biochemistry & Molecular Biology

SnapShot: p53 posttranslational modifications

Jan-Philipp Kruse et al.

Article Biochemistry & Molecular Biology

Acetylation is indispensable for p53 activation

Yi Tang et al.

Article Biochemistry & Molecular Biology

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

E. M. Michalak et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Oncology

Mdm2 and Mdm4 loss regulates distinct p53 activities

Juan A. Barboza et al.

MOLECULAR CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

Molecular basis of Pirh2-mediated p53 ubiquitylation

Yi Sheng et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Multidisciplinary Sciences

An oncogene-induced DNA damage model for cancer development

Thanos D. Halazonetis et al.

SCIENCE (2008)

Review Oncology

Telomere dysfunction and tumour suppression: the senescence connection

Yibin Deng et al.

NATURE REVIEWS CANCER (2008)

Article Biochemistry & Molecular Biology

Cellular senescence bypass screen identifies new putative tumor suppressor genes

J. F. M. Leal et al.

ONCOGENE (2008)

Article Biochemistry & Molecular Biology

The p53-Mdm2-HAUSP complex is involved in p53 stabilization by HAUSP

C. L. Brooks et al.

ONCOGENE (2007)

Review Cell Biology

p53: new roles in metabolism

Karim Bensaad et al.

TRENDS IN CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Crippling p53 activities via knock-in mutations in mouse models

T. Iwakuma et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

Restoration of p53 function leads to tumour regression in vivo

Andrea Ventura et al.

NATURE (2007)

Review Cell Biology

p53 in health and disease

Karen H. Vousden et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Modeling the therapeutic efficacy of p53 restoration in tumors

Carla P. Martins et al.

Article Multidisciplinary Sciences

p21 delays tumor onset by preservation of chromosomal

Juan A. Barboza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Oncology

Regulating the p53 pathway:: in vitro hypotheses, in vivo veritas

Franck Toledo et al.

NATURE REVIEWS CANCER (2006)

Article Cell Biology

Critical role for Daxx in regulating Mdm2

Jun Tang et al.

NATURE CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription

Shuichi Ohkubo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

J-C Marine et al.

CELL DEATH AND DIFFERENTIATION (2006)

Review Biochemistry & Molecular Biology

p53 ubiquitination: Mdm2 and beyond

CL Brooks et al.

MOLECULAR CELL (2006)

Article Oncology

Ubiquitination of p53 at multiple sites in the DNA-binding domain

WM Chan et al.

MOLECULAR CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo

G. M. Wahl

CELL DEATH AND DIFFERENTIATION (2006)

Review Oncology

Divorcing ARF and p53: an unsettled case

Charles J. Sherr

NATURE REVIEWS CANCER (2006)

Article Multidisciplinary Sciences

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

KA Krummel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

ARF-BP1/mule is a critical mediator of the ARF tumor suppressor

DL Chen et al.

Review Biochemistry & Molecular Biology

The transcriptional targets of p53 in apoptosis control

J Yu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Biochemistry & Molecular Biology

Mdmx as an essential regulator of p53 activity

JC Marine et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Cell Biology

Calorie restriction, SIRT1 and metabolism: Understanding longevity

L Bordone et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

JM Stommel et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Inhibition of p53 degradation by Mdm2 acetylation

XJ Wang et al.

FEBS LETTERS (2004)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Phosphorylation of serine 18 regulates distinct p53 functions in mice

HK Sluss et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

D MacPherson et al.

EMBO JOURNAL (2004)

Review Genetics & Heredity

The p53 response to DNA damage

DW Meek

DNA REPAIR (2004)

Article Biochemistry & Molecular Biology

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors

N Issaeva et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression

N Minsky et al.

MOLECULAR CELL (2004)

Article Multidisciplinary Sciences

The ubiquitin ligase COP1 is a critical negative regulator of p53

D Dornan et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

C Chao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

RP Leng et al.

Review Cell Biology

Tumor suppression by Ink4a-Arf:: progress and puzzles

SW Lowe et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2003)

Article Biochemistry & Molecular Biology

Acetylation of p53 inhibits its ubiquitination by Mdm2

MY Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

LD Mayo et al.

TRENDS IN BIOCHEMICAL SCIENCES (2002)

Article Biochemistry & Molecular Biology

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

D Migliorini et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Mutation of mouse p53 Ser23 and the response to DNA damage

ZQ Wu et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Cell Biology

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus

S Llanos et al.

NATURE CELL BIOLOGY (2001)

Review Biochemistry & Molecular Biology

Post-translational modifications and activation of p53 by genotoxic stresses

E Appella et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

SY Fang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Stress signals utilize multiple pathways to stabilize p53

M Ashcroft et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)