期刊
CELL RESEARCH
卷 20, 期 6, 页码 614-621出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2010.53
关键词
Mdm2; antirepression; destabilization; ubiquitination; transcriptional activation and stability
类别
资金
- NCI NIH HHS [R01 CA129627, P01 CA097403, R01 CA098821, R01 CA085533, P01 CA080058, R01 CA098821-08, R01 CA118561] Funding Source: Medline
The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene. T
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