期刊
CELL RESEARCH
卷 19, 期 12, 页码 1388-1400出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2009.113
关键词
P68 RNA helicase; nucleocytoplasm shuttle; NLS; NES; DEAD box
类别
资金
- National Institutes of Health [GM063874, CA118113]
- Georgia Cancer Coalition
- MBD fellowship
- GSU
- NATIONAL CANCER INSTITUTE [R01CA118113] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063874] Funding Source: NIH RePORTER
P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. Consistent with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus. However, recent experiments demonstrate a transient cytoplasmic localization of the protein. We report here that p68 shuttles between the nucleus and the cytoplasm. The nucleocytoplasmic shuttling of p68 is mediated by two nuclear localization signal and two nuclear exporting signal sequence elements. Our experiments reveal that p68 shuttles via a classical RanGTPase-dependent pathway.
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