期刊
CELL RESEARCH
卷 19, 期 1, 页码 116-127出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2008.326
关键词
angiogenesis; BMP; Marfan syndrome; Smad; pre-eclampsia; pulmonary hypertension; TGF-beta
类别
资金
- Centre for Biomedical Genetics
- Ludwig Institute for Cancer Research
- Dutch Cancer Society [UL-2005-3371]
- EU FP6
Transforming growth factor (TGF)-beta family members are multifunctional cytokines that elicit their effects on cells, including endothelial and mural cells, via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knock-out mouse models for TGF-beta family signaling pathway components have revealed their critical importance in proper yolk sac angiogenesis. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular syndromes such as hereditary hemorrhagic telangiectasia, primary pulmonary hypertension and Marfan syndrome. In this review, we present recent advances in our understanding of the role of TGF-beta receptor signaling in vascular biology and disease, and discuss how this may be applied therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据