Classical swine fever - an update

Classical swine fever (CSF) is a serious and contagious viral disease of pigs and wild boar with a widespread worldwide distribution. The immunopathology of the disease is poorly understood, but the ability of the CSF virus to infect cells without triggering apoptosis and to kill uninfected cells is probably highly significant. The virus may be spread by various direct and indirect methods, but in most cases the exact mechanisms involved in local spread between farms are not known. Excellent diagnostic tools and typing methods are available, but tests that could be performed on-farm, in pre-clinically infected pigs or on meat would also be advantageous. A more complete picture of the viruses circulating in different parts of the world is needed. There is great interest to develop and use marker vaccines for the control of CSF in domestic pigs and in wild boar. Epidemiological modelling is increasingly used to evaluate control options. (C) 2003 Elsevier Science Ltd. All rights reserved.