期刊
CELL RESEARCH
卷 18, 期 2, 页码 254-267出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2008.18
关键词
STAT3; DNA-binding; apoptosis; small-molecule inhibitors; cell growth; human tumors
类别
资金
- NCI NIH HHS [CA106439, R01 CA128865, R01 CA106439-05, R01 CA106439] Funding Source: Medline
Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.
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