期刊
CELL PROLIFERATION
卷 47, 期 5, 页码 381-390出版社
WILEY
DOI: 10.1111/cpr.12121
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资金
- National Natural Science Foundation of China [81201422]
- Jiangsu Province Science Foundation [BK2012334]
- 'Summit of the Six Top Talents' Program of Jiangsu Province [2013-WSW-054]
- China Postdoctoral Science Foundation [2012M5 20983]
- Innovative Foundation of Southeast University [3290002401]
Intervertebral disc degeneration (IDD) is a chronic, complex process associated with low back pain; mechanisms of its occurrence have not yet been fully elucidated. Its process is not only accompanied by morphological changes, but also by systematic changes in its histological and biochemical properties. Many cellular and molecular mechanisms have been reported to be related with IDD and to reverse degenerative trends, abnormal conditions of the living cells and altered cell phenotypes would need to be restored. Promising biological therapeutic strategies still rely on injection of active substances, gene therapy and cell transplantation. With advanced study of tissue engineering protocols based on cell therapy, combined use of seeding cells, bio-active substances and bio-compatible materials, are promising for IDD regeneration. Recently reported progenitor cells within discs themselves also hold prospects for future IDD studies. This article describes the background of IDD, current understanding and implications of potential therapeutic strategies.
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