期刊
CELL METABOLISM
卷 28, 期 3, 页码 334-336出版社
CELL PRESS
DOI: 10.1016/j.cmet.2018.08.018
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资金
- AstraZeneca
- Boehringer-Ingelheim
- Eli Lilly
- Janssen
- Merck
- Novartis
- Novo Nordisk
- Sanofi
Idiopathic pulmonary fibrosis (IPF) remains an important medical challenge, but recent translational data have provided clues implicating deficient AMPK signaling in persistently activated myelofibroblasts within fibrotic foci. A new study in Nature Medicine reports that pharmacological activation of AMPK with metformin can reverse established fibrosis by facilitating deactivation and apoptosis of myofibroblasts.
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