期刊
CELL METABOLISM
卷 19, 期 3, 页码 380-392出版社
CELL PRESS
DOI: 10.1016/j.cmet.2014.01.002
关键词
-
资金
- NIH [DK076729, DK088083, T32 DK007120, DK20579, DK56341, K99 DK094874]
Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.
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