期刊
CELL METABOLISM
卷 20, 期 5, 页码 719-730出版社
CELL PRESS
DOI: 10.1016/j.cmet.2014.10.016
关键词
-
资金
- Human Frontiers Science Program
- National Institutes of Health (NIH)
- Crohn's and Colitis Foundation of America
- Howard Hughes Medical Institute
- NIH [GM095384, AI095125, DK078938, GM099535, MH100556]
- UCSD Clinical and Translational Research Institute [UL1TR000100]
- Autism Speaks
The microbiota, and the genes that comprise its microbiome, play key roles in human health. Host-microbe interactions affect immunity, metabolism, development, and behavior, and dysbiosis of gut bacteria contributes to disease. Despite advances in correlating changes in the microbiota with various conditions, specific mechanisms of host-microbiota signaling remain largely elusive. We discuss the synthesis of microbial metabolites, their absorption, and potential physiological effects on the host. We propose that the effects of specialized metabolites may explain present knowledge gaps in linking the gut microbiota to biological host mechanisms during initial colonization, and in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据