期刊
CELL METABOLISM
卷 20, 期 2, 页码 214-225出版社
CELL PRESS
DOI: 10.1016/j.cmet.2014.05.006
关键词
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资金
- National Institute on Aging [RO1 AG028127]
- National Institute on General Medical Sciences [RO1 GM100196]
- National Eye Institute [R01 EY018177]
- Alfred Benzon Foundation
Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPRmt), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a conserved role in the long-term maintenance of cellular homeostasis. Here, we review current knowledge of the UPRmt and discuss its integration with cellular pathways known to regulate lifespan. We highlight how insight into the UPRmt is revolutionizing our understanding of mitochondrial lifespan extension and of the aging process.
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