期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 42, 期 1, 页码 17-34出版社
WILEY
DOI: 10.1002/dev.10076
关键词
maternal responsiveness/sensitivity; maternal behavior; stress; lipopolysaccharide; endotoxin; immune response; sickness behavior; mice; social behavior; social development; selective breeding; behavior genetics; individual differences
资金
- NIMH NIH HHS [MH57035-02] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH057035] Funding Source: NIH RePORTER
To examine whether maternal responsiveness during interactions with endotoxin-treated pups contributes to long-term effects on social development, neonatal mice were fostered on postnatal day 1 to dams from three selectively bred lines that differ in social behaviors. On day 5, neonates were administered saline or 0.5 mg/kg endotoxin (lipopolysaccharide, i.p.). Observations of undisturbed dams and litters on days 2, 4, 6, and 18 showed modest line differences in maternal behaviors. At the peak intensity of the transient illness induced by endotoxin, (3 hr postinjection on day 5), dams increased licking and decreased time off-nest for endotoxin, but not saline-treated pups. As adults, fostered-reared males were observed in brief social interactions. Males exposed to endotoxin early in life showed changes in adult social behaviors that depended on foster dam line as well as individual differences in maternal responsiveness. Maternal responsiveness to stressed neonates can ameliorate the social-developmental effects of early illness. (C) 2003 Wiley Periodicals, Inc.
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