期刊
CELL METABOLISM
卷 20, 期 5, 页码 827-839出版社
CELL PRESS
DOI: 10.1016/j.cmet.2014.08.011
关键词
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资金
- Canadian Institutes for Health Research
- Alberta Innovates-Health Solutions
- Alberta Innovates-Health Solutions, a Canada Research Chair
- Mazankowski Alberta Heart Institute/University Hospital Foundation
Suppression of mitochondrial function promoting proliferation and apoptosis suppression has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary arterial hypertension (PAH), but the cause of this metabolic remodeling is unknown. Mice lacking sirtuin 3 (SIRT3), a mitochondrial deacetylase, have increased acetylation and inhibition of many mitochondrial enzymes and complexes, suppressing mitochondrial function. Sirt3KO mice develop spontaneous PAH, exhibiting previously described molecular features of PAH pulmonary artery smooth muscle cells (PASMC). In human PAH PASMC and rats with PAH, SIRT3 is downregulated, and its normalization with adenovirus gene therapy reverses the disease phenotype. A loss-of-function SIRT3 polymorphism, linked to metabolic syndrome, is associated with PAH in an unbiased cohort of 162 patients and controls. If confirmed in large patient cohorts, these findings may facilitate biomarker and therapeutic discovery programs in PAH.
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