期刊
CELL METABOLISM
卷 17, 期 4, 页码 491-506出版社
CELL PRESS
DOI: 10.1016/j.cmet.2013.03.002
关键词
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资金
- Fundacion Ramon Areces
- NIH [RO1 DK35914, R01 DK56690, R01 DK074778]
- BNORC PF grant [5 P30 DK046200]
Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality control. However, quality control might not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placement of bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics might provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.
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