期刊
CELL METABOLISM
卷 18, 期 3, 页码 312-324出版社
CELL PRESS
DOI: 10.1016/j.cmet.2013.06.004
关键词
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资金
- INSERM
- Universite de Nice Sophia Antipolis
- Conseil Regional PACA
- Conseil General des Alpes-Maritimes
- Aviesan/AstraZeneca, Diabetes and the vessel wall injury program
- Agence Nationale de la Recherche (ANR)
- European Foundation for the Study of Diabetes (EFSD/Lilly
- European Diabetes Research Programme)
- Societe Francophone du Diabete, (SFD)
- Fondation pour la Recherche Medicale
In record time, microRNAs (miRNAs) have acquired the respected stature of important natural regulators of global gene expression. Multiple studies have demonstrated that a large number of miRNAs are under the control of various metabolic stimuli, including nutrients, hormones, and cytokines. Conversely, it is now well recognized that miRNAs control metabolism, thereby generating a bidirectional functional link, which perturbs energy homeostasis in case of disconnection in the miRNA-metabolism interplay. A challenging road lies ahead for defining the role of miRNAs in the pathogenesis of diseases such as diabetes and for establishing their usefulness as new medications and clinically reliable biomarkers.
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