期刊
JOURNAL OF VISION
卷 3, 期 7, 页码 513-526出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/3.7.5
关键词
horizontal cells; macaque; adaptation; outer retina; cone
资金
- NCRR NIH HHS [RR00166] Funding Source: Medline
- NEI NIH HHS [EY09625, EY01730, EY00901, EY13112] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000166] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY000901, R01EY009625, P30EY001730, R01EY013112] Funding Source: NIH RePORTER
The goal of these experiments was to define the time course and degree of cone adaptation in primate outer retina by use of probe stimuli upon temporally modulated backgrounds. Recordings were obtained from primate horizontal cells. Test probes were either a low-amplitude, high-frequency sinusoid superimposed on a slowly modulated background or small test pulses superimposed on backgrounds of various frequencies. The amplitude of the test response was modulated by the background, indicating sensitivity regulation. Results were consistent with gain controls which, at 1000 td, required similar to 10-20 ms to completion. These mechanisms could also account for some of the distortions of horizontal cell responses to sinusoids and pulses. Modulation of test responsivity occurred at low background contrasts, suggesting no threshold change in light level must be exceeded to evoke sensitivity regulation. As retinal illuminance increased from darkness, sensitivity regulation was evident at 10-20 td.
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