期刊
CELL METABOLISM
卷 16, 期 3, 页码 290-295出版社
CELL PRESS
DOI: 10.1016/j.cmet.2012.06.016
关键词
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资金
- Bolyai fellowship
- National Innovation Office (Seahorse) [FR26/2009]
- OTKA [PD83473, TAMOP-4.2.2. A-11/1/KONV-2012-0025, TAMOP-4.2.2/B-10/1-2010-0024]
- Mecenatura [Mec-8/2011]
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
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